Energy expenditure projects in critically ill children – cytokine response in various metabolic patterns – MOSF and substrate utilization

G. Briassoulis, S. Venkataraman, A Thompson

Department of Critical

Care Medicine

University of Pittsburgh,

Children's Hospital of Pittsburgh

3550 Terrace Street

Pittsburgh, PA 15261 

http://www.uoc.gr/Department/index.html

The Pediatric Intensive Care Unit research interests are focused on sepsis, trauma, respiratory distress and other stress situations. In particular research projects are dealing with nutrition and immune-nutrition in critically ill children, with energy expenditure measurements and relation to multiple organ failure and inflammatory process, and with the role of heat shock proteins in shock and stress situations.

Stress projects on R1a and Ca KO mice – Behavioral response – PKA activity in various brain areas – cFOS – CRH – cAMP studies

G. Briassoulis, M. Keil, C. Stratakis

Hatfield Clinical Research Center, Room 1-3216 NICHD, NIH, Bethesda, Maryland

301.402.1998 Fax : +1 301 402 0574

Heat shock proteins in patients with septic shock, sepsis, trauma and non-SIRS – bronchodilators in mechanically ventilated children - SID in PICU

G. Briassoulis, AM Spanaki, DM Fitrolaki, E. Kondili,

M Venihaki, D Georgopoulos

PICU and Department of Intensive

Care Medicine,

University Hospital of Heraklion,

University of Crete, Heraklion,

Crete, Greece

Balanced glutamine -mediated activation of the hsp70 - suppression of the hsp90 pathways -HPAA axis - mIF - pro- and anti-inflammatory cytokine expressionv - lymphocyte - macrophage apoptosis - restoration of glutamine levels and hsp70 gene expression will be also addressed.

G. Briassoulis, E Giamarellos-Bourboulis, S. Tsiodras, G Petrikkos

Research Laboratory on infections, 4th Clinic of Internal Medicine, ATTIKON University Hospital, University of Athens

2^nd Department of Critical Care in the Medical School of Athens University

Glutamine effect on HSP 72 and IL 17, 18, MIF expression in human peripheral blood polymorphonuclear cells. Stimulation of PBMC with E. coli and S. pneumonia in sub-cohorts stratified according to the hsp polymorphisms, hsp70/90 expression, glutamine, arginine and glutathione levels, and the HPAA level of function.

G. Briassoulis, G.Daikos, C Routsi, S. Nanas

First Critical Care Department,

National and Kapodistrian University of Athens

Evangelismos Hospital

First Department of Propaedeutic Medicine,

Research Laboratory of infectious diseases,

University of Athens,

Athens, Greece.